TITLE: “Role of the chemokine MCP-1 in sensitization of PKC-mediated apoptosis in prostate cancer cells” PRINCIPAL INVESTIGATOR:

TITLE : “ Role of the chemokine MCP - 1 in sensitization of PKC - mediated apoptosis in prostate cancer cells ” PRINCIPAL INVESTIGATOR : Marcelo

Protein kinase C (PKC) isozymes catalyze the phosphorylation of substrates that play key roles in the control in proliferation, differentiation, and survival. Treatment of cells with phorbol esters, activators of classical and novel PKC isozymes, leads to a plethora of responses in a strict cell-type–dependent specific manner. Interestingly, a few cell models undergo apoptosis in response to ph...

AWARD NUMBER: W81XWH-14-1-0535 TITLE: “Cooperativity Between Oncogenic PKC Epsilon and Pten Loss in Prostate Cancer Progression” PRINCIPAL INVESTIGATOR:

Radiosensitizing effects of Sestrin2 in PC3 prostate cancer cells

Objective(s): The stress-responsive genes of Sestrin family are recognized as new tumor suppressor genes in breast carcinoma, however, the function of Sestrin family in human prostate cancer is not clear. Ionizing radiation (IR) is known to induce Sestrin gene expression in breast cancer cells. However, the response of Sestrin to IR has not been reported in PC3 prostate cancer cells. Materials ...

W 81 XWH - 08 - 1 - 0209 TITLE : A Mechanistic Study of Proapoptotic Daxx - Par 4 Axis in Prostate Cancer PRINCIPAL INVESTIGATOR :

presentation Puto, L.A., Kitada, S., Krajewska, M., Glinsky, G., Hunter, T., and Reed, J.C. Transcriptional repressor Daxx regulates Dapk1 expression, autophagy, apoptosis, and tumorigenicity of prostate cancer cells. American Association for Cancer Research, Special Conference: Cell Death Mechanisms and Cancer Therapy; February 1-4, 2010; San Diego, California; Abstract # A7.

p53 Protein Expression and Its Relation to the Apoptotic Index in Prostate Adenocarcinoma

Background: Prostate cancer is one of the most commonly diagnosed cancers in males. Tumor suppressor gene p53 plays an important role in causing cell cycle arrest and allowing apoptosis to proceed. Objective: To investigate the expression of p53 protein and its relation to apoptosis and prostate cancer traditional prognostic indicators. Methods: In this study expression of p53 was examined in p...